Via PhysOrg.com -
Cancer cells treated with carbon nanotubes can be destroyed by noninvasive radio waves that heat up the nanotubes while sparing untreated tissue, a research team led by scientists at The University of Texas M.D. Anderson Cancer Center and Rice University has shown in preclinical experiments.
In a paper published in the journal Cancer, the researchers demonstrated that the technique completely destroyed liver cancer tumors in rabbits. There were no side effects noted. However, some healthy liver tissue within 2 to 5 millimeters of the tumors sustained heat damage due to nanotube leakage from the tumor.
"These are promising, even exciting, preclinical results in this liver cancer model," said lead investigator Steven Curley, M.D., of M.D. Anderson. "Our next step is to look at ways to more precisely target the nanotubes so they attach to, and are taken up by, cancer cells while avoiding normal tissue."
Curley conducted the research in collaboration with nanotechnology experts at Rice University and with Erie, Pennsylvania, entrepreneur John Kanzius of ThermMed LLC, who invented the experimental radiofrequency generator used in the experiments. Kanzius is a cancer survivor and former radio station owner whose insights into the potential of targeted radio waves inspired this line of research. At Rice, the work was begun by Nobel laureate Richard Smalley several months before his death from cancer in October 2005.
In the liver cancer experiment, a solution of single-walled carbon nanotubes was injected directly into the tumors. Four treated rabbits were then exposed to 2 minutes of radiofrequency treatment, resulting in thermal destruction of their tumors. Control group tumors that were treated only by radiofrequency exposure or only by nanotubes were undamaged. In lab experiments, two lines of liver cancer cells and one pancreatic cancer cell line were destroyed after being incubated with nanotubes and exposed to the radiofrequency field.
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